Drugs Testing Book

• Table of Contents
• Introduction
  • Standardized Drug Testing – Beginning of a New Revolution
  • Selection of Specimens Used for Testing
  • The Challenging Analysis of Drug Testing
  • Substituting Urine – Cheating the Test
  • Types of Laboratories
• Immunoassays and Their Screening
  • An Overview Regarding the History of Immunoassays
  • Basic Immunoassay Principles and Guidelines
  • Variety of Immunoassays Used for Illicit Drug Testing Programs for workplaces
  • Characteristics of an Immunoassay’s Performance
  • Methodology Limitations
  • Types and Mechanisms of Interference of Assays
  • Sources of Interference
  • Immunoassays and Their Application Regarding Workplace Drug Testing Programs
  • Cutoff Ranges and Result Interpretation
  • Selection and Troubleshooting of Immunoassays
  • Summary
• Confirmation via Contemporary and Latest Techniques
  • Conventional Confirmatory methods
  • Gas Chromatography
  • Liquid Chromatography (High Performance)
  • Mass Spectrometry
  • Basic Theory
  • Ionization Of Electrons
  • Chemical Ionization
  • Full Scan Analysis
  • Selected Ion Monitoring
  • Quadruple Mass Spectrometer
  • Quadruple ion Trap MS
  • Modern Method Of Drug Confirmation
  • Additional Mass Analyzers
  • Time Of Flight – Mass Spectrometers
  • Fticr-MS – Fourier Transform Ion Cyclotron Resonance – Mass Spectrometry
  • Capillary Electrophoresis
  • Summary
• Quality Assurance
  • Organization Employee Assistance Programs
  • Chain of Custody
  • Specimen Collection
  • Standard Operation Procedures
  • Personnel
  • Accessioning/Specimen Processing
  • Security
  • Internal Proficiency Testing
  • External Proficiency Testing
  • Inspection
  • Initial and Confirmation Testing
  • Equipment and Maintenance
  • Laboratory Information Management System
  • Records
  • Specimen Validity Testing
  • Quality Assurance Oversight
  • Lean Six Sigma
  • Summary
• Supervision of Regulated Workplace
  • Historical Overview
  • The Responses Of Laboratory and Regulatory Agency to the Problem
  • US Federal Regulations/Criteria
  • Scope of Adulterant/Substitution Products
  • The HHS-Certified Laboratories Experience
  • Effects of Adulterants on Analytical Tests
  • Governmental Responses to the Problem
  • Alternate Specimen Matrices
  • Summary
• Drugs of Abuse in Hair
  • Composition
  • Historical Overview
  • Sample Collection
  • Sample Preparation and Analytical Methodologies
  • Interpretive and Analytical Considerations
  • Summary
• Drug of Abuse in Oral Fluid
  • Composition
  • Historical Impression
  • Collecting The Samples
  • Sample Preparation and Analytical Methodologies
  • Summary
• Sweat Testing
  • Sweat
  • Historical Overview
  • Sweat Collection With the Patch
  • Sample Preparation and Analysis
  • Interpretations of Sweat Patch Test Results
  • Challenges
  • Summary
• Amphetamines
  • Historical Standpoint and Overview of Analytes of Interest
  • Metabolism
  • Interpretation of Results
  • Target Analyte Analytical Approaches For Workplace Drug Testing
  • Analytical Considerations and Troubleshooting
  • Established Cutoffs
  • Summary
• Opoids
  • Historical Overview
  • Mode Of Action
  • Analysis Methods
  • Drugs Pertinent to Workplace Testing
  • Interpretive Issues
  • Summary
• Phencyclidine
  • Historical Overview
  • Overview of PCP and Sample Handling
  • Results Interpretation
  • Methods of Analysis
• Cocaine
  • Historical Overview
  • Chemistry and Metabolism
  • Analytical Methods
  • Interpretation of Results
• Cannabinoids
  • Historical Overview
  • Cannabinoid Pharmacokinetics
  • Summary
• Stability of Drugs of Abuse in Biological Fluids
  • Benzodiazepines
  • Cannabinoids
  • Cocaine
  • Ethanol
  • Lysergic Acid Diethylamide
  • Opiates
  • Phencyclidine
  • Summary
• Interpretation of Workplace Drug Test Results by Medical Review Officer
  • Federal Drug-Testing Programs
  • Amphetamines
  • Cocaine
  • Marijuana
  • Opiates
  • Phencyclidine
  • Other Drugs Tested For in Workplace Programs
  • Benzodiazepines
  • Barbiturates
  • Methadone, Methaqualone, and Propoxyphene
  • Ethyl Alcohol
  • Dot-Mandated Alcohol Testing
  • Specimen Validity Testing
  • Additional MRO Functions Under the Federal Drug-Testing Programs
  • Summary
• Laboratory Accreditation & Regulation
  • Historical Overview of Workplace Drug Testing Programs
  • Accreditation Programs For Workplace Drug-Testing Laboratories
  • General Requirements (Accreditation Program Components)
  • Accreditation Body Tools
  • Impact of Regulation and Accreditation on the Drug-Testing Industry