Amphetamines have an extended history of abuse and include a significant part of drug abuse which is seen throughout the world. Analysis of this drug class is most normally limited to amphetamine and methamphetamine. Amphetamine was initially synthesized in Germany in the late 1880s but little was done with it for almost 40 years. Methamphetamine was first made in 1919. Medical use of amphetamines grew in the 1930s, when its effects on blood pressure and treatment for congestion, narcolepsy, and attention deficit hyperactivity disorder (ADHD) were discovered. The use of amphetamine in a Benzedrine Inhaler led to extensive use among asthma patients. Abuse of the inhaler started soon after its introduction by breaking open the inhaler and extorting the amphetamine from the paper impregnated strip using simple techniques like dipping the strip into a cup of coffee. Laws make the stimulant cocaine unlawful and therefore, it became more difficult be brought about by many cocaine drug test users to use amphetamine. The extensive use and abuse of the stimulants were seen in the late 1940s and 1950s and their abuse persists even till present. Originally, amphetamine and methamphetamine were placed in Schedule III, but were later moved to Schedule II drugs with legal medical indications, but an elevated potential for abuse in the early 1970s. Amphetamine and methamphetamine are at present available by prescription; current indications for use of amphetamine are attention deficit disorder, narcolepsy, and short-term weight loss. Medicinal use of l-methamphetamine-containing products in the form of inhalers as a decongestant can be obtained as over the counter (OTC); indications for the recommendation of methamphetamine include treatment of attention deficit disorder in kids and exogenous obesity.

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