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Drugs Testing Book
- Table of Contents
- Introduction
- Immunoassays and Their Screening
- An Overview Regarding the History of Immunoassays
- Basic Immunoassay Principles and Guidelines
- Variety of Immunoassays Used for Illicit Drug Testing Programs for workplaces
- Characteristics of an Immunoassay’s Performance
- Methodology Limitations
- Types and Mechanisms of Interference of Assays
- Sources of Interference
- Immunoassays and Their Application Regarding Workplace Drug Testing Programs
- Cutoff Ranges and Result Interpretation
- Selection and Troubleshooting of Immunoassays
- Summary
- Confirmation via Contemporary and Latest Techniques
- Conventional Confirmatory methods
- Gas Chromatography
- Liquid Chromatography (High Performance)
- Mass Spectrometry
- Basic Theory
- Ionization Of Electrons
- Chemical Ionization
- Full Scan Analysis
- Selected Ion Monitoring
- Quadruple Mass Spectrometer
- Quadruple ion Trap MS
- Modern Method Of Drug Confirmation
- Additional Mass Analyzers
- Time Of Flight – Mass Spectrometers
- Fticr-MS – Fourier Transform Ion Cyclotron Resonance – Mass Spectrometry
- Capillary Electrophoresis
- Summary
- Quality Assurance
- Organization Employee Assistance Programs
- Chain of Custody
- Specimen Collection
- Standard Operation Procedures
- Personnel
- Accessioning/Specimen Processing
- Security
- Internal Proficiency Testing
- External Proficiency Testing
- Inspection
- Initial and Confirmation Testing
- Equipment and Maintenance
- Laboratory Information Management System
- Records
- Specimen Validity Testing
- Quality Assurance Oversight
- Lean Six Sigma
- Summary
- Supervision of Regulated Workplace
- Historical Overview
- The Responses Of Laboratory and Regulatory Agency to the Problem
- US Federal Regulations/Criteria
- Scope of Adulterant/Substitution Products
- The HHS-Certified Laboratories Experience
- Effects of Adulterants on Analytical Tests
- Governmental Responses to the Problem
- Alternate Specimen Matrices
- Summary
- Drugs of Abuse in Hair
- Drug of Abuse in Oral Fluid
- Sweat Testing
- Amphetamines
- Opoids
- Phencyclidine
- Cocaine
- Cannabinoids
- Stability of Drugs of Abuse in Biological Fluids
- Interpretation of Workplace Drug Test Results by Medical Review Officer
- Federal Drug-Testing Programs
- Amphetamines
- Cocaine
- Marijuana
- Opiates
- Phencyclidine
- Other Drugs Tested For in Workplace Programs
- Benzodiazepines
- Barbiturates
- Methadone, Methaqualone, and Propoxyphene
- Ethyl Alcohol
- Dot-Mandated Alcohol Testing
- Specimen Validity Testing
- Additional MRO Functions Under the Federal Drug-Testing Programs
- Summary
- Laboratory Accreditation & Regulation
Summary
The oral fluid drug testing at work place is increasing due to its accessibility and simplicity, as well as its ease of use and processing, less chances of adulteration, and ability to reflect free drug concentrations in the serum. The bad part, such as short window of detection and limited sample size, are being overcome with modification to the system and also providing improvements in technology and the identification of metabolic markers in the oral fluid.
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