Naturally occurring alkaloid analgesics known as Opoids are derived from the opium poppy Papaver sominiferum. Typically, the seedpods are scored and the unify exudates contains morphine, codeine, and numerous other alkaloids, such as papaverine and thebaine. Natural Opoids, including opium, tincture of opium, and paregoric, ingredients that have been used as analgesics or drugs of abuse for centuries. There is strong confirmation of the use of opium in the Sumerian culture as early as 8500 BCE, and the writings of Theophrastus around 200 BCE describe the use of opium in Greek medicine.

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